League of Legends!!
I got this idea once I saw two of my friends -one Cho'gath and one Poppy- laning together and kicking butts like no tomorrow. Added Tristana and Teemo because yordles.
I must say this pic is pretty much the biggest challenge I've had in my whole drawing life. But I'm content the final result is exactly as I imagined it would be!
All characters (c) Riot Games